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Pregnancy causes a series of hormonal changes in your body. One group of hormones in particular, called androgens, can cause pregnancy-related acne or make existing acne worse. While you can't necessarily regulate your body's hormonal changes, you can take steps that may help prevent and treat your acne. It's important to talk about your skin care regimen with your doctor because most of the popular prescription acne medications and many of over-the-counter treatments contain ingredients that can cause serious birth defects.